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Table 1 Association of CIRBP and HIF1α expression with clinicopathological features

From: CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density

Variables

CIRBP

HIF1α

Mean fold change(± SD)

p-value

Mean fold change(± SD)

p-value

Tumor size (cm)

    

 < 5

 ≥ 5

4.213(± 0.295)

5.646 (± 0.485)

0.016*

4.027(± 0.229)

4.855 (± 0.223)

0.015*

Grade

    

 I

 II

 III

3.659(± 0.450)

4.276(± 0.362)

6.585(± 0.495)

<0.001*

3.871(± 0.337)

4.290(± 0.222)

5.075(0.296)

0.027*

Stage

    

 II

 III

4.534(± 0.322)

6.158(± 0.660)

0.018*

4.174(± 0.183)

5.317(± 0.276)

0.002*

ER

    

 Positive

 Negative

5.429(± 0.407)

4.364(± 0.467)

0.097

4.611(± 0.231)

4.337(± 0255)

0.660

PR

    

 Positive

 Negative

5.464(± 0.432)

4.434(± 0.435)

0.104

4.698(± 0.216)

4.693(± 0.214)

0.208

P53

    

 Positive

 Negative

4.420(± 0.573)

5.354(± 0.357)

0.152

4.187(0.275)

4.693(± 0.214)

0.154

Necrosis

    

 Yes

 No

5.406(± 0.437)

4.264(± 0.334)

0.045*

4.692(± 0.225)

4.154(± 0.240)

0.135

Lymphatic invasion

    

 Yes

 No

5.639(± 0.412)

3.956(± 0.365)

0.008*

4.830(± 0.223)

3.964(0.211)

0.012*

Vascular invasion

    

 Yes

 No

5.639(± 0.412)

3.956(± 0.365)

0.008*

4.830(± 0.223)

3.964(0.211)

0.012*

  1. ER = estrogen receptor, PR = progesterone receptor, CIRBP = Cold-inducible RNA-binding protein, HIF1α = Hypoxia-inducible factor 1α
  2. Fold change = describes the ratio of two values, e.g. (gene expression in condition 1)/(gene or variable expression in condition 2)
  3. * Indicates a significant difference