Table 1 Characteristics and FCN3 genotypes of the study population
From: Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease
RHD (n = 53) | Controls (n = 45) | P value | |
|---|---|---|---|
Median age, years (IQR) | 15.00 (12–20) | 21.00 (18–22) | < 0.0001 |
Female, n. (%) | 33 (62.26) | 27 (60.00%) | 0.8060 |
Country of origin, n. (%) Kenya Mozambique Namibia Nigeria South Africa Sudan Uganda Zambia Unknown | 11 (20.75) 2 (3.77) 8 (15.09) 6 (11.32) 3 (5.66) 4 (7.55) 5 (9.43) 10 (18.86) 4 (7.55) | 3 (6.67) 0 (0) 2 (4.44) 0 (0) 8 (17.78) 8 (17.78) 7 (15.56) 6 (13.33) 11 (24.44) | 0.6489 |
Median serum ficolin-3 concentration, ng/ml (IQR) | 45.90 (32.31) | 39.25 (19.99) | 0.0302 |
rs532781899 genotype, n. (%) G/G G/- -/- | 50 (94.3) 3 (5.6) 0 (0) | 44 (97.8) 1 (2.2) 0 (0) | 0.6223 |
rs4494157 genotype, n. (%) C/C C/A A/A | 42 (77.8) 9 (17.0) 2 (3.7) | 37 (82.2) 8 (17.2) 0 (0) | 0.6423 |
rs4494157 allele frequency, n. (%) C allele A allele | 96 (87.3) 14 (12.7) | 85 (90.4) 9 (9.6) | 0.4795 |