Table 5 The diagnostic performance of cut-point of three biomarkers in diagnosis of PROM by different methods
Biomarker | Methods | Cut-point | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | LR+ (95%CI) | LR− (95%CI) |
|---|---|---|---|---|---|---|---|---|
BHCG (IU/L) | Youden Euclidian Product IU DOR | 44.00 | 0.98 (0.91, 0.99) | 0.98 (0.91, 0.99) | 0.98 (0.91, 0.99) | 0.98 (0.91, 0.99) | 59.00 (8.43, 411.32) | 0.02 (0.01, 0.12) |
BUN (urea) (mmol/L) | Youden Euclidian Product IU DOR | 1..07 | 0.93 (0.84, 0.98) | 0.97 (0.88, 0.99) | 0.96 (0.88, 0.99) | 0.93 (0.84, 0.98) | 28.00 (7.16, 109.67) | 0.07 (0.03, 0.18) |
Cr (µmol/L) | Youden Euclidian Product IU | 21. 22 | 0.92 (0.82, 0.97) | 0.92 (0.82, 0.97) | 0.92 (0.82, 0.97) | 0.92 (0.82, 0.97) | 11.00 (4.74, 25.56) | 0.09 (0.04, 0.21) |
DOR | 40.6 6 | 0.68 (0.55, 0.80) | 0.98 (0.91, 0.99) | 0.98 (0.87, 0.99) | 0.76 (0.65, 0.85) | 41.00 (5.81, 287.93) | 0.32 (0.22, 0.47) |