Fig. 1

Overview of the molecular targets and organizational structure of the PINPRICS trial. A) Summary of seminal molecular mechanisms involved in the pathogenesis of paclitaxel-induced polyneuropathy and possibilities for pharmacological modulation with repurposed drugs. Modified from [10]. B) Interaction between the trial centers in the multicentric preclinical replication study PINPRICS: Study centers exchange coded trial medication and report codes and blinded measurements only to the biostatistician. All the individuals involved in the experiments and data analysis were fully blinded. Pseudonomyized data are entered into a central RedCap database via a web interface. Abbreviations: Ca²⁺, calcium; IkB, inhibitor of kappa B; IL-6, interleukin 6; IL-6 mAB, monoclonal antibody against interleukin 6; InsP₃R, inositol 1,4,5, trisphosphate receptor; NCS-1, neuronal calcium sensor 1 protein; NFkB, nuclear factor kappa B; OATP, organic-anion-transporting polypeptide; PTX, paclitaxel