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Table 2 In-vitro susceptibility of rare and emerging yeasts isolated from onychomycosis to antifungal agents

From: Molecular identification and antifungal susceptibility profile of rare and emerging yeast species causing onychomycosis

Yeast species

Antifungal

Range

GM

MIC* (µg/mL)

0.03

0.06

0.12

0.25

0.5

1

2

4

8

Candida orthopsilosis

(n = 9)

Nystatin

2–8

3.17

      

4

4

1

Fluconazole

0.25–0.5

0.46

   

1

8

    

Clotrimazole

0.03–0.12

0.04

6

2

1

      

Itraconazole

0.03–0.12

0.04

5

2

2

      

Sertaconazole

0.03–0.25

0.16

1

1

1

5

1

    

Tioconazole

0.06–0.5

0.08

 

7

1

 

1

    

Fenticonazole

0.12-2

0.28

  

2

5

1

 

1

  

Isoconazole

0.03–0.25

0.07

3

2

2

2

     

Clavispora lusitaniae

(n = 2)

Nystatin

4

4

       

2

 

Fluconazole

0.5-8

2

    

1

   

1

Clotrimazole

0.03–0.25

0.08

1

  

1

     

Itraconazole

0.06–0.25

0.12

 

1

 

1

     

Sertaconazole

0.12–0.25

0.17

  

1

1

     

Tioconazole

0.03–0.12

0.06

1

 

1

      

Fenticonazole

0.25

0.25

   

2

     

Isoconazole

0.03–0.25

0.08

1

  

1

     

Wickerhamiella pararugosa

(n = 2)

Nystatin

4

4

       

2

 

Fluconazole

0.25

0.25

   

2

     

Clotrimazole

0.03

0.03

2

        

Itraconazole

0.03–0.06

0.04

1

1

       

Sertaconazole

0.03–0.06

0.04

1

1

       

Tioconazole

0.03

0.03

2

        

Fenticonazole

0.12

0.12

  

2

      

Isoconazole

0.03–0.12

0.06

1

 

1

      

Naganishia diffluens

(n = 2)

Nystatin

4

4

       

2

 

Fluconazole

4–8

5.65

       

1

1

Clotrimazole

0.5-2

1

    

1

 

1

  

Itraconazole

0.03–0.06

0.04

1

1

       

Sertaconazole

0.12–0.25

0.17

  

1

1

     

Tioconazole

0.25-1

0.5

   

1

 

1

   

Fenticonazole

0.06

0.06

 

2

       

Isoconazole

0.03–0.06

0.04

1

1

       

Wickerhamomyces anomalus

(n = 2)

Nystatin

1–4

2

     

1

 

1

 

Fluconazole

2–4

2.82

      

1

1

 

Clotrimazole

0.25–0.5

0.35

   

1

1

    

Itraconazole

0.06–0.25

0.12

 

1

 

1

     

Sertaconazole

0.12–0.5

0.24

  

1

 

1

    

Tioconazole

0.06

0.06

 

2

       

Fenticonazole

0.12–0.5

0.24

  

1

 

1

    

Isoconazole

0.06–0.25

0.12

 

1

 

1

     

Cyberlindnera fabianii

(n = 1)

Nystatin

4

-

       

1

 

Fluconazole

2

-

      

1

  

Clotrimazole

0.12

-

  

1

      

Itraconazole

0.25

-

   

1

     

Sertaconazole

0.12

-

  

1

      

Tioconazole

0.06

-

 

1

       

Fenticonazole

0.12

-

  

1

      

Isoconazole

0.25

-

   

1

     

Meyerozyma caribbica

(n = 1)

Nystatin

8

-

        

1

Fluconazole

4

-

       

1

 

Clotrimazole

0.12

-

  

1

      

Itraconazole

1

-

     

1

   

Sertaconazole

1

-

     

1

   

Tioconazole

1

-

     

1

   

Fenticonazole

2

-

     

1

   

Isoconazole

1

-

     

1

   
  1. GM: Geometric Mean, MIC: Minimum Inhibitory Concentration
  2. *MIC determination (visual): ≥ 50% growth inhibition (azoles) or 100% inhibition (nystatin) vs. drug-free control
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BMC Research Notes

ISSN: 1756-0500

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