Table 2A Candidate cellular targets of Wort as predicted by Similarity Ensemble Approach (SEA, http://sea.bkslab.org/)
Target name | Description | P value | Max TC* |
|---|---|---|---|
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 6.449e-10 | 1.00 |
MYLK | Myosin light chain kinase, smooth muscle | 1.318e-07 | 1.00 |
MTOR | Serine/threonine-protein kinase mTOR | 3.315e-07 | 1.00 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 6.808e-05 | 1.00 |
PLK3 | Serine/threonine-protein kinase PLK3 | 0.001813 | 1.00 |
PRKDC | DNA-dependent protein kinase catalytic subunit | 0.01538 | 1.00 |
PLK1 | Serine/threonine-protein kinase PLK1 | 0.08118 | 1.00 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.388 | 1.00 |
PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 0.5107 | 1.00 |
HSP90AA1 | Heat shock protein HSP 90-alpha | 0.6738 | 1.00 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.8021 | 1.00 |
OPRK1 | Kappa-type opioid receptor | 1.055e-14 | 0.34 |