Table 3 Genotype and allele frequency distribution of polymorphisms in infertile patients and controls
Genotypes and alleles | Patient group | Control group | OR (95% CI) | Uncorrectedp | Corrected p |
|---|---|---|---|---|---|
n (%) | n (%) | ||||
Interleukin33-rs1048274 (G > A) | |||||
GG | 63 (31.5) | 122 (61) | 0.6 (0.3–1) | 0.087 | 0.061 |
AA | 34 (17) | 22 (11) | 1.2 (0.6–2.2) | 0.005 | 0.009 |
GA | 103 (51.5) | 55 (27.5) | 3.4 (2.2–5.2) | < 0.001 | < 0.005 |
G | 229 (57.3) | 299 (75.1) | 0.6 (0.5–0.7) | 0.000 | 0.004 |
A | 171 (42.8) | 99 (24.9) | 1.4 (1.2–1.6) | 0.001 | 0.002 |
Interleukin33-rs16924243 (T > C) | |||||
CC | 134 (67) | 44 (22) | 1.6 (1.06–2.5) | 0.002 | 0.003 |
TT | 22 (11) | 25 (12.5) | 0.40 (0.22–0.70) | 0.001 | 0.002 |
TC | 152 (76) | 20 (10) | 2.5 (1.1–5.4) | 0.002 | 0.005 |
C | 222 (55.5) | 192 (48.7) | 1.02 (0.46–2.26) | 0.009 | < 0.0001 |
T | 178 (44.5) | 202 (31.3) | 0.9 (0.45–1.7) | 0.077 | 0.093 |
Interleukin22-rs1397852121 (C > T) | |||||
CC | 95 (47.5) | 121 (60.5) | 0.5 (0.3–0.8) | 0.009 | < 0.0001 |
TT | 18 (9) | 11 (5.5) | 1.6 (0.7–3.6) | 0.001 | 0.003 |
TC | 87 (43.5) | 68 (34) | 1.4 (0.99–2.2) | 0.005 | 0.007 |
C | 277 (69.5) | 310 (77.5) | 0.6 (0.40–0.93) | 0.021 | 0.001 |
T | 123 (30.8) | 90 (22.5) | 1.8 (0.02–1.06) | 0.006 | < 0.0001 |
Interleukin22-rs1295978671(C > T) | |||||
CC | 95 (47.5) | 91 (45.5) | – | 0.819 | 0.867 |
TT | 19 (9.5) | 17 (8.5) | – | ||
TC | 86 (43) | 92 (46) | – | ||
C | 276 (69) | 274 (68.5) | – | 0.879 | 0.090 |
T | 124 (31) | 126 (31.5) | – | ||
Interleukin22-rs2227483(A > T) | |||||
AA | 80 (53) | 120 (60) | 1.9 (1–2.3) | 0.046 | 0.050 |
TT | 17 (8.5) | 9 (4.9) | 1.1 (0.2–1.4) | < 0.001 | < 0.002 |
AT | 103 (38.5) | 71 (35.1) | 1.7 (0.9–1.9) | 0.001 | 0.001 |
A | 97 (254.6) | 303 (75.7) | 0.8 (1.4–2.2) | 0.000 | 0.001 |
T | 103 (74.4) | 97 (24.3) | 0.5 (1.3–2.6) | 0.000 | 0.000 |
Interleukin17A-rs2275913 (G > A) | |||||
GG | 80 (40) | 121 (60.5) | 0.4 (0.2–0.6) | 0.001 | 0.002 |
AA | 19 (9.5) | 5 (2.5) | 5.7 (2.06–16.01) | < 0.001 | < 0.004 |
GA | 101 (51) | 74 (37) | 2.06 (1.3–3.1) | 0.001 | 0.001 |
G | 261 (45.2) | 316 (54.8) | 0.3 (0.2–0.6) | 0.000 | 0.0001 |
A | 139 (62.3) | 84 (37.7) | 2 (1.4–2.7) | 0.000 | 0.003 |
Interleukin17F-rs763780 (T > C) | |||||
CC | 37 (18.5) | 13 (6.5) | 8.1 (3.9–16.5) | < 0.001 | 0.000 |
TT | 47 (23.5) | 134 (67) | 1.2 (0.5–3) | 0.063 | 0.056 |
TC | 116 (58) | 53 (26.5) | 6.2 (3.9–9.9) | < 0.001 | 0.000 |
C | 190 (70.6) | 79 (29.4) | 3.6 (2.6–5.03) | < 0.001 | 0.000 |
T | 210 (39.5) | 321 (60.5) | 0.3 (0.2–0.5) | 0.000 | 0.003 |
Interleukin13-1512 (A > C) | |||||
AA | 74 (42.5) | 100 (57.5) | 0.8 (0.6–1.1) | 0.043 | 0.035 |
CC | 19 (67.9) | 9 (32.1) | 1.3 (0.15–0.8) | 0.01 | 0.02 |
AC | 57 (58.2) | 41 (41.8) | 1.5 (0.3–0.8) | 0.01 | 0.01 |
C | 95 (61.7) | 59 (38.3) | 1 (0.3–0.7) | 0.001 | 0.000 |
A | 205 (46) | 241 (54) | 0.3 (0.2–05) | 0.000 | 0.004 |
Interleukin13-2044 (G > A) | |||||
GG | 6 (35.3) | 11 (64.7) | 0.3 (0.1–0.9) | 0.037 | 0.043 |
AA | 93 (61.6) | 58 (38.4) | 1.8 (1.05–1.09) | 0.006 | < 0.0001 |
AG | 81 (61.4) | 51 (38.6) | 1.3 (0.2–0.6) | 0.000 | 0.001 |
A | 237 (54.6) | 197 (45.4) | 1.2 (0.4–1.4) | 0.000 | 0.003 |
G | 63 (38) | 103 (62) | 0.5 (0.3–0.7) | 0.000 | 0.005 |
Interleukin4-rs2243250(C > T) | |||||
CC | 45 (22.5) | 102 (51) | 3.2 (1.9–4.8) | 0.000 | 0.003 |
TT | 37 (18.5) | 25 (12.5) | 3.3 (1.8–6.2) | 0.000 | 0.004 |
CT | 118 (59) | 73 (36.5) | 3.6 (2.3–5.7) | 0.000 | 0.001 |
C | 208 (42.9) | 277 (57.1) | 2 (1.5–2.7) | 0.000 | 0.000 |
T | 192 (61) | 123 (39) | 1.8 (1.1–1.9) | 0.000 | 0.001 |
Interleukin4-rs2070874(C > T) | |||||
CC | 83 (41.5) | 110 (55) | 1 (1.1–1.4) | 0.000 | 0.006 |
TT | 17 (8.5) | 8 (4) | 0.3 (0.1–0.8) | 0.01 | 0.03 |
CT | 100 (50) | 82 (41) | 0.6 (0.4–0.9) | 0.02 | 0.03 |
C | 266 (46.8) | 302 (53.2) | 1.2 (1.6–2.9) | 0.000 | 0.005 |
T | 134 (57.8) | 98 (42.2) | 0.6 (04–0.8) | 0.005 | 0.009 |