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Table 4 Correlation between red cell parameters and haemoglobin types/variant in patients with type 2 diabetes mellitus

From: Haemoglobin types and variant interference with HbA1c and its association with uncontrolled HbA1c in type 2 diabetes mellitus

HbAIc status

Red cell parameter

Statistics

HbF

HbA0

HbA2

HbAS

HbA1c < 7%  (< 53 mmol/mol) [Controlled]

/non-diabetic or prediabetic

HbA1c ≥ 7% (≥ 53 mmol/mol)

[Uncontrolled]/ Diabetic

RBC (X10^6/µL

r

0.096

-0.096

-0.067

0.062

p value

0.425

0.424

0.578

0.605

Hb (g/dL)

r

-0.130

-0.092

-0.088

0.089

p value

0.276

0.442

0.461

0.458

HCT (%)

r

-0.023

-0.271

-0.097

0.292

p value

0.847

0.021

0.415

0.013

MCV fL

r

-0.291

0.198

0.223

-0.151

p value

0.013

0.096

0.060

0.206

MCH (pg)

r

-0.298

-0.009

-0.053

0.033

p value

0.011

0.938

0.660

0.786

MCHC (g/dL

r

-0.019

0.057

-0.092

-0.033

p value

0.875

0.636

0.441

0.785

RBC (X10^6/µL

r

-0.102

0.046

-0.047

-0.072

p value

0.392

0.699

0.693

0.549

Hb (g/dL)

r

-0.068

0.085

-0.210

-0.095

p value

0.570

0.476

0.077

0.427

HCT (%)

r

-0.131

0.112

0.025

-0.145

p value

0.273

0.348

0.835

0.225

MCV fL

r

-0.019

0.152

0.176

-0.136

p value

0.872

0.202

0.139

0.256

MCH (pg)

r

0.016

0.041

-0.181

-0.016

p value

0.894

0.735

0.128

0.892

MCHC (g/dL

r

0.038

-0.068

-0.389

0.087

p value

0.748

0.572

0.001

0.468

  1. Association between red cell parameters and haemoglobin types/variant in participants with controlled and uncontrolled HbA1c was determined using Pearson correlation. p values in bold are statistically significance at p < 0.05. Abbreviations: RBC -Red cell count, MCV; Mean cell volume, MCH; Mean cell haemoglobin and MCHC; Mean cell haemoglobin concentration, HbA0; Major adult haemoglobin, HbA2; Minor adult haemoglobin, HbAA; Homozygous wild type of the normal haemoglobin and HbAS; Heterozygous sickle cell trait