Fig. 2

Histological sections of NMR skin from the shoulder region obtained after topical application of Vaseline (a) and imiquimod cream (b) for eight days. There are no changes in the skin structure after application of Vaseline or IMQ, with no leucocyte infiltration nor vascular congestion and the straight boundary between epidermis (E) and dermis (D) is maintained. Epidermis of NMR that received topical IMQ for 8Â days (c) showing a well-formed stratum granulosum (arrow)