Table 1 Association analysis of allele frequency and genotype distribution between POAG cases and controls
SNP locus | Gene type | Controls (%) | POAG (%) | OR (95% CI) | p valuea |
|---|---|---|---|---|---|
Rs693421 | GG | 43 (25.10 | 45 (24.3) | 1.00 | Reference |
GT | 91 (53.2) | 89 (48.1) | 0.93 (0.56–1.56) | 0.791 | |
TT | 37 (21.6) | 51 (27.6) | 1.32 (0.73–2.39) | 0.362 | |
Additive | – | – | – | 0.417 | |
Dominant | – | – | 1.05 (0.65–1.69) | 0.860 | |
Recessive | – | – | 1.38 (0.85–2.24) | 0.190 | |
G | 177 (52.0) | 179 (48.0) | 1.00 | Reference | |
T | 165 (48.0) | 191 (52.0) | 1.15 (0.85–1.54) | 0.368 | |
HWE P | 0.390 | 0.616 | – | – | |
Rs2499601 | TT | 48 (28.1) | 47 (25.4) | 1.00 | Reference |
TC | 80 (46.7) | 80 (43.2) | 1.02 (0.61–1.70) | 0.920 | |
CC | 43 (25.1) | 58 (31.4) | 1.38 (0.78–2.42) | 0.265 | |
Additive | – | – | – | 0.429 | |
Dominant | – | – | 1.18 (0.72–1.92) | 0.512 | |
Recessive | – | – | 1.36 (0.85–2.16) | 0.195 | |
T | 176 (51.0) | 174 (47.0) | 1.00 | Reference | |
C | 166 (49.0) | 196 (53.0) | 1.19 (0.89–1.60) | 0.236 | |
HWE P | 0.406 | 0.072 |