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Fig. 2 | BMC Research Notes

Fig. 2

From: Synthesis of γ-hydroxy-α-(arylmethyl)carboxylic acids from lactones: pathway to a structural motif derived from lactic acid and amino acid analogs?

Fig. 2

Synthesis of 4-hydroxy-2-(arylmethyl)carboxylates starting from (E)-3-benzylidendihydrofuran-2-one (6) and (E)-5-methyl-3-((N-methylpyrazol-4-yl)methylene)furan-2-one (7), hydrogenation to 3-benzyldihydrofuran-2-one (8) and 5-methyl-3-((N-methylpyrazol-4-yl)methyl)dihydrofuran-2-one (9) and finally saponification to sodium 4-hydroxy-2-(phenylmethyl)butanoate (4) and sodium 4-hydroxy-2-((N-methylpyrazol-4-yl)methyl)pentanoate (3)

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BMC Research Notes

ISSN: 1756-0500

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