Figure 2
From: Cellular phosphatases facilitate combinatorial processing of receptor-activated signals
Phosphatase-dependent regulation provides for the generation of signal plasticity. Panels A, B and C depict the effect of silencing of either PP1 (●), PP2A (○), MKP3 (◆), MKP1 (□), MKP2 (■), SHP2 (∇), HePTP (▲), PP2B (▼), SHP1 (△) or PTP1B (◇) on peak phosphorylation levels, initial phosphorylation rate and rate of de-phosphorylation respectively on representative examples, as compared to that obtained for cells treated with non-silencing siRNA (dashed line in panel A, or * in panels B and C).